This Special Issue will enlighten readers about new discoveries, advances, and development in cancer therapeutics. This Special Issue welcomes the submission of original research and review articles focusing on cancer signaling pathways and therapeutics however, research on new technologies employed for studying cancer biomarker identification, tracing cancer pathways, that will help us to understand cancer biology in depth is also welcome. The main objectives are not restricted to apoptosis, necrosis, autophagy, ferroptosis or lysosomal signaling cascade but also target various pathways for tumor annihilation, cell death for intrinsic and extrinsic apoptosis, novel plants, chemical drugs, nanomedicine or strategies targeting cancer promoting proteins (BH3, SMAC mimetics, cFLIP, XIAP). This Special Issue focuses on “Cancer Signaling Pathways, Crosstalk and Therapeutics”. Therefore, it is vital to consider all of these factors for chemotherapy. Moreover, tumor microenvironment has a significant impact on cell proliferation, death, metabolism and chemotherapy. Both mechanisms are complex, however, apoptosis, autophagy, necrosis, or necroptosis signaling cascade plays a crucial role. Both cell growth and cell death are important mechanisms for cancer proliferation, development and for chemoresistance. Cell death is an essential biological process in maintaining homeostasis, as well as in removing dead cells. Therefore, it is important to study cancer in depth. Cancer ranks second, next to cardiovascular diseases, for causing the greatest number of deaths. Cancer is a major problem of disease worldwide and, each year, many millions of people are diagnosed with cancer around the world, and more than half of them die.
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